【摘 要】
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The centrosome is a membrane-less organelle consisting of a pair of barrel-shaped centrioles and pericentriolar material and functions as the major microtubule-organizing center and signaling hub in animal cells.The past decades have witnessed the functio
【机 构】
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Institute of Biomedical Sciences,College of Life Sciences,Shandong Normal University,Jinan 250014,Ch
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The centrosome is a membrane-less organelle consisting of a pair of barrel-shaped centrioles and pericentriolar material and functions as the major microtubule-organizing center and signaling hub in animal cells.The past decades have witnessed the functional complexity and importance of centrosomes in various cellular processes such as cell shaping,division,and migration.In addition,centrosome abnormalities are linked to a wide range of human diseases and pathological states,such as cancer,re-productive disorder,brain disease,and ciliopathies.Herein,we discuss various functions of centrosomes in development and health,with an emphasis on their roles in germ cells,stem cells,and immune responses.We also discuss how centrosome dys-functions are involved in diseases.A better understanding of the mechanisms regulating centrosome functions may lead the way to potential therapeutic targeting of this orgnelle in disease treatment.
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