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目的:比较甲氨蝶呤联合米非司酮、开腹手术以及腹腔镜手术治疗异位妊娠的临床疗效。方法:将120例异位妊娠患者分为3组,每组40例,A组予以甲氨蝶呤联合米非司酮保守治疗,B组行开腹手术,C组行腹腔镜手术,比较3组临床疗效、血清孕酮与β-HCG变化情况及恢复正常时间,比较术者手术时间及术中出血量。结果:B、C组治愈率明显高于A组(P<0.05);C组患者血清孕酮及β-HCG值较A、B组下降快,恢复所需时间短(P<0.05);且C组手术时间短于B组,术中出血量少于B组(P<0.05)。结论:腹腔镜手术治疗异位妊娠优于开腹手术,甲氨蝶呤联合米非司酮保守治疗具有可行性,但应严格掌握适应证。
Objective: To compare the clinical efficacy of methotrexate combined with mifepristone, laparotomy and laparoscopic surgery for ectopic pregnancy. Methods: 120 cases of ectopic pregnancy were divided into 3 groups, 40 cases in each group, group A methotrexate combined with mifepristone conservative treatment, group B underwent laparotomy, group C laparoscopic surgery, compared with 3 Group clinical efficacy, serum progesterone and β-HCG changes and return to normal time, operation time and intraoperative blood loss. Results: The cure rates of group B and C were significantly higher than those of group A (P <0.05). The serum progesterone and β-HCG values of group C were significantly lower than those of group A and B (P <0.05) The operation time of group C was shorter than group B, and the amount of bleeding during operation was less than that of group B (P <0.05). Conclusions: Laparoscopic surgery is superior to laparotomy in the treatment of ectopic pregnancy. Methotrexate combined with conservative treatment of mifepristone is feasible, but indications should be strictly controlled.