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Ｗｉｓｔａｒ雌、雄大鼠在交配前每周一次ｉｖ给予去乙酰基长春花碱酰胺硫酸盐（ｖｉｎｄｅｓｉｎｅｓｕｌｆａｔｅ，ＶＤＳ），共分别给药３次和９次，各组剂量分别为０．０５ｍｇ／ｋｇ、０．１ｍｇ／ｋｇ、０．２ｍｇ／ｋｇ。１∶１同笼交配２ｗｋ，期间继续按前给药，孕鼠于孕期第６、１２ｄ各给药一次。结果各剂量组雄鼠体重增重明显减少；高剂量组孕鼠死胎率增加，胎仔尾长和体重明显小于对照组；各剂量组胎仔骨骼发育迟缓，未见外观、内脏和骨骼畸形。结果表明ＶＤＳ对Ｗｉｓｔａｒ大鼠具有胚胎毒性，无致畸作用，对两性生育能力未见明显影响
Wistar female and male rats were given iv vindesine sulfate (VDS) once a week before mating, and were administered 3 times and 9 times respectively. The doses of each group were 0.05 mg / kg, 0 .1 mg / kg, 0.2 mg / kg. 1: 1 with the cage mating 2wk, during the continuation of pre-press, pregnant rats in pregnancy on the 6th, 12d each time. Results The body weight gain of male rats in each dose group was significantly reduced. The stillbirth rate and the tail length and body weight of the pregnant rats increased significantly in the high dose group. The skeletal growth rate of the fetuses in each dose group was delayed, and the appearance, internal organs and skeletal deformity were not observed. The results showed that VDS had embryotoxicity, no teratogenic effect on Wistar rats and no significant effect on the fertility of the two sexes