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目的探讨初诊2型糖尿病患者应用精蛋白锌重组赖脯胰岛素混合注射液(50R)(优泌乐50)强化治疗的效果和用药依从性。方法 72例初诊2型糖尿病患者随机分为对照组37例和观察组35例。对照组于三餐前15min皮下注射门冬胰岛素,晚22:00皮下注射甘精胰岛素;观察组三餐前15min皮下注射优泌乐50;2组均连续用药14d。检测2组治疗前、治疗14d后空腹血糖(fasting plasma glucose,FPG)、餐后2h血糖(2-hour plasma glucose,2hPG);出院后随访2个月,记录2组自行停药患者比率。结果观察组治疗14d后FPG[(6.54±0.81)mmol/L]、2hPG[(9.66±1.24)mmol/L]较治疗前[(12.22±3.91)、(17.87±3.47)mmol/L]降低(P<0.05);对照组治疗14d后FPG[(6.43±0.73)mmol/L]、2hPG[(9.27±1.18)mmol/L]较治疗前[(12.52±4.03)、(17.82±3.54)mmol/L]降低(P<0.05);2组治疗14d后FPG、2hPG水平比较差异无统计学意义(P>0.05);观察组胰岛素日用量与对照组比较差异无统计学意义(P>0.05);出院后2个月,对照组自行停药患者比率(40.5%)高于观察组(17.1%)(P<0.01)。结论初诊2型糖尿病患者应用优泌乐50强化治疗血糖控制效果满意,患者出院后治疗依从性较高。
Objective To investigate the effect and medication compliance of intensive treatment of patients with newly diagnosed type 2 diabetes with protamine zinc combined with insulin lispro injection (50R) (Urged 50). Methods 72 patients with newly diagnosed type 2 diabetes were randomly divided into control group (37 cases) and observation group (35 cases). In the control group, aspartic insulin was subcutaneously injected 15min before meals and insulin glargine was injected subcutaneously 22:00 at night. In the observation group, suberect doses of Ursolicol 50 were administered subcutaneously 15min before meals. The two groups were given continuous medication for 14 days. The fasting plasma glucose (FPG) and 2-hour plasma glucose (2hPG) were measured before treatment and after treatment for 14 days. The patients were followed up for 2 months after discharge. Results FPG [(6.54 ± 0.81) mmol / L] and 2 hPG [(9.66 ± 1.24) mmol / L] in the observation group decreased significantly compared with [(12.22 ± 3.91) and (17.87 ± 3.47) mmol / L] P <0.05). FPG [(6.43 ± 0.73) mmol / L], 2hPG [(9.27 ± 1.18) mmol / L] in the control group were significantly lower than those before treatment [(12.52 ± 4.03) vs (17.82 ± 3.54) mmol / L] (P <0.05). There was no significant difference in FPG and 2hPG levels between the two groups after 14 days of treatment (P> 0.05). There was no significant difference in the daily dosage of insulin between the two groups (P> 0.05) At 2 months after discharge, the rate of self-discontinuation in the control group (40.5%) was higher than that in the observation group (17.1%) (P <0.01). Conclusion The patients with newly diagnosed type 2 diabetes treated with Urged 50 are satisfied with the control of blood glucose, and the patients are discharged with satisfactory compliance after treatment.