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目的:比较局部或全身应用抗生素加龈下刮治及根面平整的机械治疗对广泛性侵袭性牙周炎临床疗效的影响。方法:采用随机分组方法分为局部使用盐酸米诺环素组、口服阿莫西林+甲硝唑组和单纯龈下刮治及根面平整的治疗组,通过观察各项临床牙周指数在治疗前后的变化,比较三组之间的疗效差异。结果:三组的各项临床牙周指数较治疗前均有显著性差异(P<0.01),治疗后局部用药组和全身用药组的龈沟出血指数(SBI)、探诊深度(PD)和附着水平丧失(CAL)均较单纯机械治疗组有显著性差异(P<0.01),但局部用药组和全身用药组之间SBI、PD、CAL的无显著性差异(P>0.05)。结论:局部或全身应用抗生素均可有效提高广泛性侵袭性牙周炎的临床疗效,且两者疗效无显著性差异。
Objective: To compare the effects of topical or systemic antibiotics plus subgingival scaling and root-surface mechanical treatment on the clinical efficacy of extensive invasive periodontitis. Methods: Randomized divided into local use of minocycline hydrochloride group, oral amoxicillin + metronidazole group and subgingival curettage and root surface formation of the treatment group, by observing the clinical periodontal index in the treatment Before and after the change, the difference between the efficacy of the three groups. Results: The clinical periodontal indexes in all three groups were significantly different from those before treatment (P <0.01). After treatment, the SBI, PD and There were significant differences in the level of adhesion loss (CAL) between the local drug group and the systemic drug group (P <0.01), but there was no significant difference in the SBI, PD and CAL between the local drug group and the systemic drug group (P> 0.05). Conclusion: Topical or systemic antibiotics can effectively improve the clinical efficacy of extensive invasive periodontitis, and there is no significant difference between the two.