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目的:观察幽门螺杆菌感染患者及非感染患者药物过敏率的差异。方法:采用13C尿素呼吸试验结合胃镜下胃黏膜快速尿素酶试验检测幽门螺杆菌阳性率,病史结合青霉素皮试确定药物过敏。结果:幽门螺杆菌感染组的药物过敏率为19.00%,非感染组的药物过敏率35.14%,P<0.05,有统计学意义。结论:幽门螺杆菌感染患者的药物过敏率低于非感染患者,显示幽门螺杆菌感染对人群免疫机制可能有影响。
Objective: To observe the difference of drug allergy between Helicobacter pylori and non-infected patients. Methods: The positive rate of Helicobacter pylori was detected by 13C urea breath test combined with gastroduodenal mucosa rapid urease test. The history was combined with penicillin skin test to determine the drug allergy. Results: The rate of drug allergy was 19.00% in Helicobacter pylori infection group and 35.14% in non-infected group, P <0.05, which was statistically significant. Conclusions: The rates of drug allergy in patients with H. pylori infection are lower than those in non-infected patients, indicating that H. pylori infection may have an impact on the immune mechanism in the population.