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目的对孕中期胎儿进行唐氏综合征(DS)、神经管缺陷(NTD)和18-三体综合征的筛查和诊断,减少患儿的出生。方法对山东省滕州市妇幼保健院产科门诊7644例孕15~20周孕妇,用化学发光法进行血清生化标志物甲胎蛋白(AFP)、绒毛膜促性腺激素(HCG)及游离雌三醇(uE3)浓度检测,利用配套软件计算胎儿患DS、NTD和18-三体综合征的风险。结果筛查的7644例孕妇中,DS阳性421例,236例做确诊检查,阳性12例;NTD筛查阳性58例,5例确诊;18-三体综合征筛查阳性51例,35例做确诊检查,阳性1例。结论孕中期进行产前筛查,可减少缺陷患儿出生率,具有重要社会价值。
Objective To screen and diagnose Down’s syndrome (DS), neural tube defects (NTD) and 18-trisomy syndrome in the second trimester fetus to reduce their birth. Methods A total of 7644 pregnant women, aged from 15 to 20 weeks pregnant, were included in the obstetric outpatient department of Maternal and Child Health Hospital of Tengzhou City, Shandong Province. The levels of serum biochemical markers AFP, HCG and free estriol uE3) concentration test, the use of software to calculate fetal risk of DS, NTD and 18-trisomy syndrome. RESULTS: Of the 7644 pregnant women who were screened, 421 cases were positive for DS and 236 cases were confirmed as positive. Twelve cases were positive in screening, 58 cases were positive for NTD screening, 5 cases were confirmed, 51 cases were positive for 18-trisomy, and 35 cases were done Confirmed examination, positive in 1 case. Conclusion Prenatal screening during the second trimester can reduce the birth rate of children with defects and has important social value.