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目的对比观察奥美拉唑与雷尼替丁治疗十二指肠溃疡的临床疗效及用药安全法。方法选择本院内科收治的活动性十二指肠溃疡患者50例,随机分为治疗组25例(应用奥美拉唑为主)和对照组(应用雷尼替丁为主),治疗组服用奥美拉唑,对照组应用雷尼替丁,两组且同时应用抗幽门螺杆菌(Hp)及保护黏膜等常规治疗,疗程4周,疗程结束后,治疗组治疗愈合率为92%,总有效率为100%;对照组溃疡愈合率56.0%,总有效率为84%,两组比较差异有统计学意义(P<0.01),两组治疗期间均未出现明显的不良的反应,用药安全。结论奥美拉唑有较大的抑制胃酸分泌作用,且由于抑酸剂负反馈的作用,引起高胃泌素血症,增加黏膜血流量,从而加速溃疡愈合,临床疗效显著优于雷尼替丁。
Objective To compare the clinical efficacy of omeprazole and ranitidine in the treatment of duodenal ulcer and the drug safety law. Methods Fifty patients with active duodenal ulcer admitted to our hospital were randomly divided into treatment group (n = 25) (dominated by omeprazole) and control group (dominated by ranitidine). The treatment group Omeprazole, the control group ranitidine, two groups and at the same time the application of anti-Helicobacter pylori (Hp) and protective mucosa and other conventional treatment, the course of 4 weeks after treatment, the treatment group healing rate was 92%, total The effective rate was 100%; the control group ulcer healing rate was 56.0%, the total effective rate was 84%, the difference between the two groups was statistically significant (P <0.01), no significant adverse reactions during the treatment of both groups, medication safety . Conclusion Omeprazole has a greater inhibitory effect on gastric acid secretion, and due to the negative feedback effect of antacid, causing hypergastrinemia, increasing mucosal blood flow and thus accelerating the healing of ulcers, the clinical efficacy is significantly better than that of ranitidine Ding.