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采用免疫组化方法，应用一组抗癌胚抗原（ＣＥＡ）、上皮膜抗原（ＥＭＡ）和不同分子量细胞角蛋白的抗体，对７８例鼻咽癌癌旁上皮的上皮性标志物的表达进行了研究。结果表明，柱状上皮的储备细胞和鳞状上皮的基底细胞的上皮性标志物表达不同。在柱状上皮的鳞状化生过程中，一方面是柱状上皮的储备细胞增生并转化为鳞状上皮的“基底细胞”；另一方面，这些“基底细胞”按照正常鳞状上皮的分化程序，分化并发育成鳞状上皮，但仍保留储备细胞的一些分化特征。因此，鳞化上皮与正常被覆鳞状上皮在上皮性标志物表达上仍存在一些差异。
Immunohistochemistry was used to detect the expression of epithelial markers in 78 paracancerous nasopharyngeal epithelial tissues using a panel of anti-carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA) and antibodies of different molecular weight cytokeratin the study. The results showed that the epithelial markers of basal cells in the columnar epithelial cells and squamous epithelium were expressed differently. During squamous metaplasia of the columnar epithelium, on the one hand, the reserve cells of the columnar epithelium proliferate and transform into “basal cells” of the squamous epithelium; on the other hand, these “basal cells” follow the normal squamous epithelial differentiation process, Differentiate and develop into squamous epithelium, but still retain some of the differentiation characteristics of the reserve cells. Therefore, there is still some difference in the expression of epithelial markers between squamous epithelium and normal squamous epithelium.