【摘 要】
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Dear Editor,Flotillin-1 (Flot1,reggie-2) is a lipid raft-associated scaffolding protein that belongs to a family of proteins characterized by an evolutionarily
【机 构】
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School of Life Sciences,Institutes of Brain Science and State Key Laboratory of Medical Neurobiology
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Dear Editor,Flotillin-1 (Flot1,reggie-2) is a lipid raft-associated scaffolding protein that belongs to a family of proteins characterized by an evolutionarily conserved SPFH domain (Browman et al.,2007;Langhorst et al.,2008).Although flotillin-1 is ubiquitously expressed,it is known to be highly expressed in brain tissue,and has been shown to serve distinct functions in the nervous system.Flotillin-1 has been shown to be necessary for axonal regeneration of retinal ganglion cells (Munderloh et al.,2009) and the differentiation and outgrowth of hippocampal neurons while additionally promoting the formation of glutamatergic synapses in the hippocampus (Swanwick et al.,2010).Recently,flotillin-1 has been identified as an evolutionarily-conserved memory related protein,involved in leaing and memory processes (Monje et al.,2013).However,the ability of flotillin-1 to modulate critically important ion channel proteins,which are the most highly expressed membrane protein in brain,has not been previously demonstrated.
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