【摘 要】
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OBJECTIVE:To investigate the efficacy and mecha-nism of the Qingre Huayu Fang(清热化瘀方)on atherosclerotic vulnerable plaque in apolipopro-tein E(ApoE)knockout
【机 构】
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De-partment of Cardiology,Guizhou Provincial People’s Hospi-tal,Guiyang 520000,China;Department of H
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OBJECTIVE:To investigate the efficacy and mecha-nism of the Qingre Huayu Fang(清热化瘀方)on atherosclerotic vulnerable plaque in apolipopro-tein E(ApoE)knockout mice through the ubiquitin proteasome pathway.METHODS:Sixty 8-week-old C57BL/6J ApoE knock-out mice were fed a high-fat for 12 weeks and ran-domly divided into four treatment groups(n = 15 each):high-fat control,bortezomib(a proteasome inhibitor),bortezomib combined with Qingre Hua-yu Fang,and Qingre Huayu Fang alone.Aortic sec-tions were examined for plaque development,in-flammatory cell infiltration,type Ⅰ/Ⅲ collagen ex-pression and immunohistochemical staining of CD40L,nuclear factor-kappa B(NF-κB)/P65 and ubiquitin.RESULTS:Mice in the high-fat control group had obvious atherosclerosis,with increased aortic plaque area.The degree of atherosclerosis of the atherosclerotic plaque was reduced in all of the treatment groups that received bortezomib and/or Duzhong(Cortex Eucommiae)Qingre Huayu.The ex-pression of NF-κB,CD40L and ubiquitin were all re-duced in the group that received combination bort-ezomib+Qingre Huayu Fang.CONCLUSION:The Qingre Huayu Fang inhibited aortic atherosclerosis in mice through a mecha-nism that may involve inhibition of the ubiquitin proteasome pathway.
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