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目的分析副溶血弧菌所致急性肠炎患者的临床表现、流行病学、菌株血清分型、耐药性分析及临床意义。方法对2010年6月至2012年12月所分离的副溶血弧菌进行病例临床信息统计,菌株血清分型与抗生素敏感试验。结果副溶血弧菌感染的临床表现为腹痛、腹泻、恶心、呕吐、发烧等典型胃肠炎反应。发病高峰在8-9月,以青壮年为主,主要与外出聚餐、食用海鲜产品及食用生和半生食品有关。血清型中以O3:K6为主,占80%;O1:K1占15.24%;O4:K1仅占4.76%。副溶血弧菌对抗生素有较高的敏感性,只对氨苄西林有很高的耐药性。结论副溶血弧菌感染症状典型、有季节性、人群分布差异性,已成为我国一个严重的食源性公共卫生问题之一。不同地区流行的副溶血弧菌的菌株存在较大的差异,必须持续地进行主动监测和污染控制,做到有的放矢。
Objective To analyze the clinical manifestations, epidemiology, serotyping, drug resistance and clinical significance of patients with acute enteritis caused by Vibrio parahaemolyticus. Methods The clinical information of Vibrio parahaemolyticus isolated from June 2010 to December 2012 were collected. The strains were serotyped and antibiotics sensitive test. Results The clinical manifestations of Vibrio parahaemolyticus infection were abdominal pain, diarrhea, nausea, vomiting, fever and other typical gastroenteritis reactions. Peak incidence in August-September, mainly young and middle-aged, mainly with eating out, eating seafood products and eating raw and semi-finished food-related. Serum O3: K6-based, accounting for 80%; O1: K1 accounted for 15.24%; O4: K1 only accounted for 4.76%. Vibrio parahaemolyticus antibiotics have a higher sensitivity, only high resistance to ampicillin. Conclusion The symptoms of Vibrio parahaemolyticus are typical, seasonal and population distribution differences, and have become one of the serious foodborne public health problems in our country. Vibrio parahaemolyticus strains that are endemic in different regions have great differences. Therefore, it is necessary to carry out active monitoring and pollution control on a continuous basis and achieve a definite goal.