【摘 要】
：
Aim: To investigate the relationships of serum testosterone, insulin-like growth factor (IGF)-I and IGF-binding protein(IGFBP)-3 levels with prostate cancer risk and also with known prognostic parameters of prostate cancer in Korean men who received radic
【机 构】
：
Department of Urology,Seoul National University Bundang Hospital,Seongnam 463-707,Korea
论文部分内容阅读
Aim: To investigate the relationships of serum testosterone, insulin-like growth factor (IGF)-I and IGF-binding protein(IGFBP)-3 levels with prostate cancer risk and also with known prognostic parameters of prostate cancer in Korean men who received radical retropubic prostatectomy (RRP) for clinically-localized prostate cancer. Methods: Serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 were determined in 592 patients who subsequently received prostate biopsy. Results were compared between patients who eventually received RRP for prostate cancer (n = 159) and those who were not diagnosed with prostate cancer from biopsy (control group, n = 433). Among the prostate cancer only patients, serum hormonal levels obtained were analyzed in relation to serum prostate specific antigen (PSA),pathological T stage and pathological Gleason score. Results: Prostate cancer patients and the control group demon-strated no significant differences regarding serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 across the different age groups. Among the cancer only patients, no significant associations were observed for serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 levels with pathological T stage, pathological Gleason score and preoperative PSA. Conclusion: Our data indicate that simple quantifications of serum testosterone and IGF-1 along with IGFBP-3 levels might not provide useful clinical information in the diagnosis of clinically localized prostate cancer in Korean men. Also, our results suggest that serum levels of testosterone, IGF-1 and IGFBP-3 might not be significantly associated with known prognostic factors of clinically localized prostate cancer in Korean men.
其他文献
Aim: To evaluate the efficacy and safety of SK3530, a newly developed type 5 phosphodiesterase inhibitor (PDE5I), in Korean men with erectile dysfunction (ED). Methods: A total of 119 patients were randomized at 10 centers in Korea to receive either SK353
Aim: To elucidate effects and mechanisms of emodin in prostate cancer cells. Methods: Viability of emodin-treated LNCaP cells and PC-3 cells was measured by MTT assay. Following emodin treatments, DNA fragmentation was assayed by agarose gel electrophores
Aim: To develop a method for assessing sperm function by measuring released acrosin activity during the acrosome reaction (AR). Methods: Human semen samples were obtained from 24 healthy donors with proven fertility after 3-7 days of sexual abstinence. Af
Luminal acidification in the epididymis is an important process for the regulation of male fertility. Low pH and low bicarbonate concentration are among key factors that keep spermatozoa in a dormant state while they mature and are stored in this organ. A
Aim: To investigate effects of quercetin on weight and histology of testis and accessory sex organs and on sperm quality in adult male rats. Methods: Male Sprague-Dawley rats were injected s.c. with quercetin at the dose of 0, 30,90, or 270 mg/kg body wei
Aim: To investigate the rates of prostate cancer (Pca) in radical cystoprostatectomy (RCP) specimens for bladder cancer in mainland China. To determine the follow-up outcome of patients with two concurrent cancers and identify whether prostate-specific an
Dear Editor,I am Dr Xiao-Yu Yang,from the Center of Clinical Reproductive Medicine in the First Affiliated Hospital at the NanJing Medical University,Nanjing,China.We present here a case report of a globozoospermic patient whose partner became pregnant af
Aim: To study polyethylenimine (PEI)-mediated in vivo gene transfection into testis cells and preliminary functional research of spermatogenic cell-specific gene NYD-SP12 using this method. Methods: PEI/DNA complexes were introduced into the seminiferous
Aim: To identify the serum biomarkers of prostate cancer (PCa) by protein chip and bioinformatics. Methods:Serum samples from 83 PCa patients and 95 healthy men were taken from a mass screening in Changchun, China.Protein profiling was carried out using s