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目的:多烯磷脂酰胆碱治疗抗结核药物致药物性肝炎疗效。方法:选取2014年9月到2015年9月期间本院所收治的81例抗结核药物致药物性肝炎患者作为研究对象,将患者随机分为观察组41例和对照组40例。对照组采用肌苷、肝泰乐以及门冬氨酸钾镁治疗,观察组采用多烯磷脂酰胆碱联合治疗,对比两组患者的临床治疗效果。结果:对照组临床治疗总有效率为90%,观察组患者临床治疗总有效率为97.56%,观察组患者临床治疗效果显著优于对照组患者,两组之间差异对比具有统计学意义(P<0.05)。结论:多烯磷脂酰胆碱治疗抗结核药物致药物性肝炎疗效较为显著,患者康复效果较为理想,值得在临床治疗中广泛推广和应用。
OBJECTIVE: To investigate the curative effect of polyene phosphatidylcholine on drug-induced hepatitis induced by anti-TB drugs. Methods: From September 2014 to September 2015, 81 patients with drug-induced hepatitis due to anti-tuberculosis drugs admitted to our hospital were selected as study subjects. Patients were randomly divided into observation group (41 cases) and control group (40 cases). The control group was treated with inosine, giletic, and potassium magnesium aspartate. The observation group was treated with polyene phosphatidylcholine, and the clinical effects of the two groups were compared. Results: The total effective rate in the control group was 90%. The total effective rate in the observation group was 97.56%. The clinical effect in the observation group was significantly better than that in the control group. The difference between the two groups was statistically significant (P <0.05). Conclusion: The therapeutic effect of polyene phosphatidylcholine on drug-induced hepatitis induced by antituberculosis drugs is significant, and the rehabilitation effect of patients is ideal, so it is worth to be widely popularized and applied in clinical treatment.