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缺血后处理是在缺血预处理基础上提出的新概念,因其对器官缺血-再灌注损伤具有良好的保护作用,应用性强,且具有事后性,目前已成为研究保护器官缺血-再灌注损伤方面的热点。但缺血后处理的确切机制及有效诱导时间窗等问题尚不清楚。因此,我们就其发现、发展(远隔后处理、药物后处理)、对心脏、肺、肝、肾和脑等的保护、机制及诱导时间窗等研究新进展进行综述。
Ischemic postconditioning is a new concept proposed on the basis of ischemic preconditioning. Because of its good protective effect on organ ischemia-reperfusion injury, it has strong applicability and posterior function. It has become a research project to protect organ ischemia Reperfusion injury in the hot spots. However, the exact mechanism of ischemic postconditioning and the problem of effectively inducing time windows are not yet clear. Therefore, we reviewed the recent progress in the discovery, development (aftertreatment, drug reprocessing) of cardiac, lung, liver, kidney and brain protection, mechanisms and induction time windows.