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Blood flow under various conditions of vessel is simulated as a non-Newtonian fluid by the two-dimensional Lattice Boltzmann method,in which the Casson model is used to express the relationship between viscosity and shear rate of the blood.The flow field distributions at certain sites near the narrowing and bifurcation of the vessel explain the hemodynamic mechanism of the preclilection of the atherosclerotic lesions for these sites which are consistent with that found by medical studies.