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目的探讨川崎病患儿不同时期凝血功能与疾病进展的关系,为指导临床诊治、减少后天性心血管疾病提供科学依据。方法监测KD组和对照组患儿不同时期凝血功能及与冠状动脉病变发生的关系。结果①KD组患儿D-二聚体升高者极显著高于对照组(P<0.01);②动态观察KD组与对照组D-二聚体升高比较<7d组、7～14d组差异均极显著(P<0.01),>14d组无差异(P>0.05);③CAD组与NCAD组D-二聚体升高比较无差异(P>0.05);④动态观察CAD组与NCAD组D-二聚体升高比较<7d组无差异(P>0.05),7～14d组差异极显著(P<0.01),>14d组有显著差异(P<0.05)。结论D-二聚体可作为KD早期诊断的重要指标之一,动态观察D-二聚体具有预测冠状动脉损伤的价值。
Objective To investigate the relationship between coagulation function and disease progression in children with Kawasaki disease in different periods and to provide scientific basis for clinical diagnosis and treatment and to reduce acquired cardiovascular diseases. Methods The relationship between coagulation function and the incidence of coronary artery disease in children with KD and control at different periods was monitored. Results ① The increase of D-dimer in KD group was significantly higher than that in control group (P <0.01); ② Dynamic observation of the increase of D-dimer in KD group and control group <7d group, 7-14d group (P> 0.05); ③Compared with NCAD group, there was no significant difference in D-dimer between CAD group and NCAD group (P> 0.05) (P <0.05). The difference between the 7th and 14th days was significant (P <0.01), and the difference was significant between> 14 days (P <0.05). Conclusion D-dimer can be used as one of the important indicators for the early diagnosis of KD. The dynamic observation of D-dimer can predict the value of coronary artery injury.