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Ehreberger和Brix(1983)研究谷氨酸对耳鸣的影响,应用二乙基酯酶谷氨酸(GDEE)(一种谷氨酸桔抗药)和谷氨酸(Glu)静脉注射,获得较好效果。为了评价这种治疗,作者报告一组应用GDEE和GIu治疗耳鸣的病例。本组21例均为以前治疗无效又不能进行手术治疗的患者,病因未加选择。年龄范围为31至77岁,症状期从5个月至17年。试验前耳鸣频率匹配为500～12000赫兹,强度范围为15～110dB。患者中老年性聋7例,噪声损伤4例,美尼尔氏病4例,原因不明8例,耳蜗耳硬化症2例,耳硬化症1例。2例为双侧耳鸣。GDEE
Ehreberger and Brix (1983) studied the effect of glutamate on tinnitus, using diethyl esterase glutamate (GDEE) (a glutamic acid resistant) and glutamate (Glu) intravenously to obtain better effect. To evaluate this treatment, the authors report a case-control study of tinnitus patients with GDEE and GIu. The group of 21 patients were previously treated ineffective patients can not be treated, the etiology did not add choice. The age range is 31 to 77 years and the symptoms range from 5 months to 17 years. Tinnitus frequency before the test match 500 ~ 12000 Hz, the intensity range of 15 ~ 110dB. There were 7 cases of senile deafness, 4 cases of noise damage, 4 cases of Meniere’s disease, 8 cases of unknown cause, 2 cases of ear otosclerosis and 1 case of otosclerosis. 2 cases of bilateral tinnitus. GDEE