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目的探讨妊娠期肝内胆汁淤积症(ICP)产妇分娩时期的选择对母儿并发症的影响。方法选择2012年1月-2016年12月该院收治的295例ICP产妇为研究对象,分为两组,对照组148例给予常规治疗,观察组147例在对照组治疗基础上给予药物治疗,同时选择合理的分娩时机,统计孕妇一般情况、分娩孕周、分娩方式、产妇及新生儿并发症的发生情况,并进行比较分析。结果分娩孕周、剖宫产率、早产率、自发性早产率、医源性早产率等两组差异有统计学意义(t=5.765,χ~2=15.457、5.192、9.081、6.983,均P<0.05);出生体质量、产后出血两组差异有统计学意义(t=1.939,χ~2=7.582,均P<0.05),但Apgar评分、新生儿窒息率、围生儿死亡率、住院时间、羊水污染等两组差异无统计学意义(t=1.034,χ~2=0.524、1.847,t=0.945,χ~2=1.276,均P>0.05)。结论根据ICP孕妇的病情程度和胎儿情况,可适当延长分娩孕周,选择恰当的分娩时机可有效降低早产率和剖宫产率,减少产妇及新生儿并发症,改善妊娠结局。
Objective To investigate the effect of pregnancy maternal cholecystosis (ICP) on maternal and child complications during childbirth. Methods From January 2012 to December 2016, 295 pregnant women with ICP who were admitted to our hospital were divided into two groups. 148 cases in the control group were given routine treatment. 147 cases in the observation group were treated with drugs on the basis of the control group, At the same time choose a reasonable timing of delivery, statistics of the general situation of pregnant women, gestational birth, mode of delivery, maternal and neonatal complications, and comparative analysis. Results The gestational weeks of childbirth, cesarean section rate, premature birth rate, spontaneous preterm birth rate and iatrogenic preterm birth rate had statistical significance (t = 5.765, χ ~ 2 = 15.457, 5.192, 9.081, 6.983, P <0.05). There were significant differences in the birth weight and postpartum hemorrhage between two groups (t = 1.939, χ ~ 2 = 7.582, all P <0.05), but Apgar score, neonatal asphyxia, perinatal mortality, There was no significant difference between the two groups in time, amniotic fluid contamination (t = 1.034, χ ~ 2 = 0.524, 1.847, t = 0.945, χ ~ 2 = 1.276, all P> 0.05). Conclusion According to the degree of ICP pregnant women and fetal status, may be appropriate to extend the gestational age of childbirth, choose the appropriate timing of delivery can effectively reduce the rate of preterm birth and cesarean section, reduce maternal and neonatal complications and improve pregnancy outcomes.