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目的探究阿德福韦酯联合拉米夫定治疗乙型肝炎肝硬化的临床效果。方法随机抽取96例乙型肝炎肝硬化患者，均分为研究组与对照组，对照组给予拉米夫定，研究组采取阿德福韦酯联合拉米夫定的治疗方法，对比观察两组治疗效果。结果治疗后，两组HBV-DNA水平有所降低，然而研究组HBV-DNA水平降低更为明显，两组差异具有统计学意义(<0.05)。结论对乙型肝炎肝硬化治疗而言，相较于拉米夫定，阿德福韦酯联合拉米夫定的临床疗效显著，能够迅速降低HBV-DNA水平，有效改善临床症状。“,”Objective To explore the clinical ef ect of adefovir and lamivudine in treatment of hepatitis B cir hosis.Methods 96 cases were randomly selected hepatitis B liver cir hosis patients and divided into study group and control group,the control group were given lamivudine,the research group take adefovir and lamivudine treatment,compared to observe the therapeutic ef ect of the two groups.Results After treatment,the levels of HBV-DNA in the two groups were decreased,but the level of HBV-DNA in the study group was more obvious,and the dif erence between the two groups was statistical y significant ( <0.05).Conclusion For the treatment of hepatitis B cir hosis,compared to lamivudine,adefovir and lamivudine clinical curative ef ect,can rapidly reduce the level of HBV-DNA,ef ectively improve the clinical symptoms.