Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma:Feasi

• 作 者: Oge Tascilar Gldeniz Karadeniz Cakmak Ishak Ozel Tekin Ali Ugur Emre Bulent Hamdi Ucan Oktay Irkorucu Kemal Karakaya Mesut Gl Hseyin Blent Engin Mustafa Comert
• 机 构: Department of Surgery Zonguldak Karaelmas University,The School of Medicine,Kozlu-Zonguldak 67600,Tu
• 出 处: World Journal of Gastroenterology
• 发表日期: 2007年41期
• 关键词: colorectal NCAM prognostic routine experienced differentiated proximal criterion

AIM: To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice. METHODS: Twenty-six patients (16 men,10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression. RESULTS: Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However,NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage Ⅱ?disease who experienced no active disease at 30 mon follow-up. CONCLUSION: As a consequence of the limited number of cases in our series,it might not be possible to make a generalisation,nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.

AIM: To evaluate the frequency of neural cell adhesion molecule (NCAM) -180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice. METHODS: Twenty-six patients (16 men, 10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression. RESULTS: Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of However, NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage II® disease who experienced no active disease at 30 mon follow-up. CONCLUSION: As a consequence of the limited number of cases in our series, it might not be possible to make a generalization, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.