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目的在作“成人接种BCC预防结核、肿瘤等病群组对照监测研究”中,恰逢流行性感冒(流感)暴发,随即对研究对象进行流感发病情况的调查,探讨成人接种BCG对流感的预防作用。方法选一个乡的20～55岁健康村民,随机分为接种BCG的研究组和未接种的对照组。对接种组于1997年5月首次接种,11月第2次接种,1998年5月第3次接种,以后进入观察监测期,对发生的相关疾病由防疫网络医生及时进行调查、登记,每月报告,年底小结。1999年8月发生流感暴发,立即对它作专题调查,从中核对出接种组和未接种组中流感的发生情况并进行统计分析。结果①本次流感暴发,该镇在家的研究对象计7079人,发生流感者425人,其中未接种BCG的是3498人,发生流感337人,接种BCG的3581人,发生流感88人,两群组间流感的发病率相比较有非常显著差异;②接种BEG 1次的2261人,发生流感50人,接种2次的1016人,发生流感26人,接种3次的304人,发生流感12人。经统计学处理,BCG不同接种次数群组间流感的发病率无显著差异(X~2=3.430,P=0.180)。结论①成人接种BEG后约2.5年对流感有很好的预防作用(保护率74.49％);②成人接种BCG预防流感在约2.5年中不必要加强免疫,即这期间复种不能再提高机体对流感的预防作用。
Objectives In the “adult vaccination BCC prevention tuberculosis, cancer and other disease group monitoring study”, coincides with the outbreak of influenza (influenza), then the study of the incidence of influenza in the investigation to explore the adult vaccination BCG prevention of influenza effect. Methods A healthy villager from 20 to 55 years old in a township was randomly divided into study group inoculated with BCG and unvaccinated control group. The inoculation group was first vaccinated in May 1997, the second vaccination in November and the third vaccination in May 1998, and then entered the observation and monitoring period. The epidemic prevention network doctors were investigated and registered for the related diseases in a timely manner. Report, summary at the end An outbreak of influenza was reported in August 1999 and a special investigation was conducted immediately. The incidence of influenza in vaccinated and non-vaccinated groups was checked out and statistical analysis was conducted. Results ① The outbreak of this flu accounted for 7079 people at home in the town with 425 flu patients, of which 3498 were uninfected with BCG, 337 were flu and 3581 were BCG vaccinated. There were 88 flu and two There was a significant difference in the incidence of influenza between the two groups. (2) There were 2261 people who inoculated with BEG once, 50 people who developed influenza, 2 people who inoculated 2 times, 26 people who had flu, 304 people who had 3 inoculation and 12 people who had flu . Statistically, there was no significant difference in the incidence of influenza between BCG vaccinated groups (X ~ 2 = 3.430, P = 0.180). CONCLUSIONS ① Approximately 2.5 years after inoculation of BEG in adults have a good preventive effect on influenza (protection rate 74.49%); ② It is not necessary to strengthen immunity in BCG prevention adults vaccinated by adults for about 2.5 years. In other words, The preventive effect.