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目的探讨2型糖尿病(T2DM)患者非增生型视网膜病变(NPDR)与颈动脉内膜中层厚度(IMT)之间的关系。方法选择NPDR组97例,糖尿病正常眼底(NDR)对组照100例。B超检测IMT。结果 (1)NPDR组IMT明显高于NDR组(P<0.01)。(2)NPDR与年龄、病程、收缩压、舒张压、糖化血红蛋白、IMT、尿白蛋白呈正相关(P<0.05),与HDL-C、餐后2hC肽呈负相关(P<0.05)。Logis-tic回归显示IMT是NPDR的主要危险因素(P<0.01)。(3)IMT增厚组(60.7%)NPDR发病率明显高于正常组(44.1%)(P<0.05)。结论 T2DM合并颈动脉IMT增厚者NPDR发病率显著增高,推测动脉粥样硬化可能是NPDR的一个重要的相关因素。
Objective To investigate the relationship between non-proliferative retinopathy (NPDR) and carotid intima-media thickness (IMT) in type 2 diabetes mellitus (T2DM). Methods Ninety-seven cases of NPDR and 100 cases of normal diabetic retinopathy (NDR) were enrolled. B-test IMT. Results (1) The IMT in NPDR group was significantly higher than that in NDR group (P <0.01). (2) NPDR was positively correlated with age, duration of disease, systolic blood pressure, diastolic blood pressure, glycosylated hemoglobin, IMT and urinary albumin (P <0.05), but negatively correlated with HDL-C and postprandial 2h peptide (P <0.05). Logistic regression showed that IMT was the main risk factor of NPDR (P <0.01). (3) The incidence of NPDR in IMT thickening group (60.7%) was significantly higher than that in normal group (44.1%) (P <0.05). Conclusion The incidence of NPDR in patients with T2DM complicated with carotid IMT thickening is significantly higher. It is speculated that atherosclerosis may be an important correlate of NPDR.