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Objective:To study the antibacterial activity of the leaf methanol extracts of five different species of Vitex namely,Vilex altissima(V.allissima),Vitex diversifolia(V.diversifolia),Vitex negundo(V.negundo),Vitex peduncularis(V.peduncularis) and Vitex trifolia(V.trifolia). Methods:Antibacterial assay was carried out by using disc diffusion method,determination of minimum inhibitory concentrations(MIC) and minimum bactericidal concentrations(MBC) against five strains of Gram-positive and seven strains of Gram-negative human pathogenic bacterial strains.Results:The results of antibacterial activity of Vitex species showed that the extracts possessed a broad spectrum of antibacterial activity.The V.peduncularis possessed the highest activity against all the microorganisms screened.It produced a zone of inhibition ranged between (11.000±0.577) and(22.670±0.667) mm and the MIC values were from 62.5 to I 000.0μg/mL and the MBC values were from 125.0 to 2 000.0μg/mL.Conclusions:Based on the present study, V.peduncularis is recommended for the isolation of antibacterial molecule responsible for the activity against the tested human pathogenic bacterial strains.
Objective: To study the antibacterial activity of the leaf methanol extracts of five different species of Vitex namely, Vilex altissima (V.allissima), Vitex diversifolia (V.diversifolia), Vitex negundo (V.negundo), Vitex peduncularis ) and Vitex trifolia (V.trifolia). Methods: Antibacterial assay was carried out by using disc diffusion method, determination of minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) against five strains of Gram-positive and seven strains of Gram -negative human pathogenic bacterial strains. Results: The results of antibacterial activity of Vitex species showed that the extracts possessed a broad spectrum of antibacterial activity. V.peduncularis possessed the highest activity against all the microorganisms screened. It produced a zone of inhibition ranged between (11.000 ± 0.577) and (22.670 ± 0.667) mm and the MIC values were from 62.5 to 1000.0 μg / mL and the MBC values were from 125.0 to 2 000.0 μg / mL. Conclusions: Based on t he present study, V. peduncularis is recommended for the isolation of antibacterial molecule responsible for the activity against the tested human pathogenic bacterial strain.