论文部分内容阅读
目的 研究增殖细胞核抗原 (PCNA)和CD44V6表达与胃癌侵袭转移及预后的关系 ,探讨胃癌组织PCNA和CD44V6表达的相互关系。方法 采用SP免疫组化染色方法 ,检测 90例胃癌组织PCNA和CD44V6的表达情况。结果 胃癌组织PCNA标记指数 (LI)为6 3 83 %± 17 16 % ,CD44V6阳性表达率为 74 4% (6 7 90 ) ;PCNALI和CD44V6表达强度与胃癌淋巴结转移、浸润深度及TNM分期均呈显著正相关 (P <0 .0 5 ) ;PCNALI≥ 5 0 %或CD44V6强阳性表达的胃癌患者术后 1,3 ,5年生存率均显著降低 (P <0 .0 5 ) ;CD44V6阳性表达胃癌组织的PCNALI显著高于CD44V6阴性表达者 (P <0 .0 5 )。结论 PCNA和CD44V6表达与胃癌侵袭转移及预后显著相关 ;CD44V6的表达可能有助于胃癌增殖活性的增加
Objective To investigate the relationship between the expression of proliferating cell nuclear antigen (PCNA) and CD44V6 and the invasion, metastasis and prognosis of gastric carcinoma and to explore the correlation between the expression of PCNA and CD44V6 in gastric carcinoma. Methods SP immunohistochemical staining was used to detect the expression of PCNA and CD44V6 in 90 cases of gastric cancer. Results The PCNA labeling index (LI) of gastric cancer was 63.33% ± 17.16% and the positive rate of CD44V6 was 74.4% (67.90). The expressions of PCNA and CD44V6 were significantly correlated with lymph node metastasis, depth of invasion and TNM stage in gastric cancer (P <0.05). The survival rates at 1, 3, 5 years after operation in gastric cancer patients with PCNALI ≥ 50% or strong positive for CD44V6 were significantly decreased (P0.05) .The positive expression of CD44V6 The PCNALI of gastric cancer was significantly higher than that of CD44V6 negative (P <0.05). Conclusions The expressions of PCNA and CD44V6 are significantly correlated with the invasion, metastasis and prognosis of gastric cancer. The expression of CD44V6 may contribute to the increase of proliferative activity of gastric cancer