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目的观察醒脑通脉化瘀方对急性脑梗死患者血清超敏-C反应蛋白(hs-CRP)、白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平的影响。方法将急性脑梗死患者160例随机分为研究组和对照组各80例。对照组依据2010年版中国急性缺血性脑卒中诊治指南分析患者危险因素给予规范药物治疗,研究组在对照组基础上加用中药合剂—醒脑通脉化瘀组方,2组均治疗2周。比较2组治疗前后患者hs-CRP、IL-1β、TNF-α水平变化。结果治疗前,2组患者血清hs-CRP、IL-1β、TNF-α水平比较,差异无统计学意义(P>0.05)。治疗后,2组hs-CRP、IL-1β、TNF-α均较治疗前降低,且研究组降低幅度大于对照组,差异均有统计学意义(P<0.05)。结论醒脑通脉化瘀方可以明显抑制急性脑梗死患者血清hs-CRP、IL-1β、TNF-α水平,抑制机体氧化应激反应,起到加强脑保护作用。
Objective To observe the effect of Xingnaotongmai Huayu Recipe on the serum levels of hs-CRP, IL-1β and TNF-α in patients with acute cerebral infarction. Methods 160 patients with acute cerebral infarction were randomly divided into study group and control group of 80 cases. Control group according to the 2010 edition of China’s guidelines for the diagnosis and treatment of acute ischemic stroke patients analysis of risk factors given to the standard drug treatment, the study group in the control group based on the use of Chinese medicine mixture - Xingnao Tongmai Huayu prescription, two groups were treated for 2 weeks . The changes of hs-CRP, IL-1β and TNF-α in two groups before and after treatment were compared. Results Before treatment, there was no significant difference in serum hs-CRP, IL-1β, TNF-α levels between the two groups (P> 0.05). After treatment, the levels of hs-CRP, IL-1β, TNF-α in the two groups were lower than those before treatment, and the reduction rate in the study group was greater than that in the control group. The difference was statistically significant (P <0.05). Conclusions Xingnao Tongmai Huayu Recipe can significantly inhibit the serum levels of hs-CRP, IL-1β and TNF-α in patients with acute cerebral infarction and inhibit the oxidative stress in the body, which plays a role in enhancing brain protection.