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目的：观察单味附子煎剂治疗类风湿性关节炎的临床疗效。方法患者120例，随即分成治疗组和对照组，分别采用单味附子煎剂治疗和口服甲氨蝶呤+来氟米特片治疗，观察治疗前后临床症状、体征及血沉（ESR）、C反应蛋白（CRP）、类风湿因子（RF）等实验室指标的变化。结果治疗组总疗效优于对照组（P<0.01），在缓解临床症状、体征及降低血沉、C反应蛋白、类风湿因子等实验室指标方面亦明显优于对照组（P<0.01）。结论单味附子煎剂治疗类风湿性关节炎在临床取得良好疗效，为进一步提取附子中的有效治疗成分制成制剂提供依据。“,”Objective To observe the clinical effect of the single aconite in treating rheumatoid arthritis.Methods A total of 120 patients were rondomly divided into treatment and control groups,the treatment group was treated by the single aconite and the control group was treated with oral Methotrexate and Leflunomide,the changes of clinical symptoms、signs、ESR、CRP and RF were observed.Results The treatment group had obvious advantages than the control group in the total clinical effect、relieving the clinical symptoms and signs、lowing laboratory index (ESR、CRP and RF).Conclusion Single aconite has a good effect in treating rheumatoid arthritis,and provide the basis for further extraction of the active ingredient aconite.