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目的观察并比较天麻眩晕宁颗粒加减结合盐酸氟桂利嗪治疗高血压性眩晕的临床效果。方法将70例高血压性眩晕患者随机分为实验组和对照组各35例,实验组口服天麻眩晕宁颗粒(每次8 g,每日3次)联合盐酸氟桂利嗪胶囊(每次10 mg,每晚1次)。对照组仅服用眩晕宁颗粒,用法同实验组。2个月后观察两组患者的疗效,比较两组治疗前后TCD变化、血液流变学改变。结果实验组显效27例,有效6例,无效2例,总有效率为94.29%;对照组显效20例,有效7例,无效8例,总有效率为77.14%;两组总有效率比较差异有统计学意义(P<0.05)。经治疗后TCD检查结果提示两组患者的左右椎动脉(LVA、RVA)及基底动脉(BA)的平均流速均有明显提高(t=5.76~6.43,P<0.05);实验组相较于对照组有显著差异(tLVA=2.67,P<0.05;tRVA=3.89,P<0.05;tBA=2.87,P<0.05)。两组患者治疗后血液流变学指标(血液粘度,红细胞压积、红细胞聚集指数及纤维蛋白原)均有明显降低(t=2.06~8.24,P<0.05);实验组相较于对照组有显著差异(t值分别为2.00、3.04、2.23、3.07,P<0.05)。结论天麻眩晕宁颗粒联合盐酸氟桂利嗪能显著提高高血压性眩晕症的疗效,提高椎-基底动脉供血,降低血液粘滞度,无明显副作用,值得临床推广。
Objective To observe and compare the clinical efficacy of Tianma Dazhuning Granules plus Flunarizine Hydrochloride in the treatment of hypertensive vertigo. Methods Seventy patients with hypertensive vertigo were randomly divided into experimental group (35 cases) and control group (35 cases). The experimental group was given Tianma dizhuning granule (8 g, 3 times daily) combined with Flunarizine Hydrochloride Capsule mg, once per night). The control group only took dizzy ning granule, usage and experimental group. Two months later, the curative effect of two groups was observed. TCD changes and hemorheological changes were compared between the two groups before and after treatment. Results In the experimental group, 27 cases were markedly effective, 6 cases were effective and 2 cases were ineffective. The total effective rate was 94.29%. In the control group, 20 cases were markedly effective, 7 cases effective and 8 ineffective, with a total effective rate of 77.14%. The total effective rate was significantly different There was statistical significance (P <0.05). After treatment, the results of TCD showed that the average velocity of left and right vertebral artery (LVA, RVA) and basilar artery (BA) were significantly increased in both groups (t = 5.76 ~ 6.43, P <0.05) Group had significant differences (tLVA = 2.67, P <0.05; tRVA = 3.89, P <0.05; tBA = 2.87, P <0.05). After treatment, the indexes of hemorheology (blood viscosity, hematocrit, erythrocyte aggregation index and fibrinogen) in both groups were significantly decreased (t = 2.06-8.24, P <0.05); compared with the control group Significant differences (t values were 2.00,3.04,2.23,3.07, P <0.05). Conclusion Tianma dizziness Ning granules combined with flunarizine hydrochloride can significantly improve the efficacy of hypertensive vertigo, improve vertebrobasilar artery blood supply, reduce blood viscosity, no obvious side effects, is worth clinical promotion.