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Dear EditorrnTo date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019 (COVID-19).As a newly emerged member of
【机 构】
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Institute for Interdisciplinary Information Sciences,Tsinghua University,Beijing 100084,China;Beijin
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Dear EditorrnTo date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019 (COVID-19).As a newly emerged member of the coronavirus family,SARS-CoV-2 is an enveloped positive-strand RNA virus,which has probably the largest genome (approximately 30 kb) among all RNA viruses.The nucleocapsid (N) protein of SARS-CoV-2 is mainly responsible for recognizing and wrapping viral RNA into helically symmetric structures (Malik,2020).It was also reported that N protein can boost the efficiency of transcription and replication of viral RNA,implying its vital and multifunctional roles in the life cycle of coronavirus(Surjit and Lal,2008;Chang et al.,2014).Recently,several independent research teams have reported that N protein of SARS-CoV-2 is capable of undergoing liquid-liquid phase separation (LLPS) (Iserman et al.,2020;Perdikari et al.,2020;Savastano et al.,2020).
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