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目的分析新生儿巨细胞病毒感染的危险因素,并提出干预对策。方法选取2010年10月-2012年11月于我院就诊的巨细胞病毒感染患儿作为研究对象,也选取同期在我院生产的45例健康新生儿作为对照组,标本采集,采用PCR、ELISA分别检测CMV-DNA、CMV-IgG、CMVIgM的水平。结果检测95份尿液中50例CMV-DNA为阳性,其阳性率为52.63%,50例CMV-DNA为阳性的新生儿母亲乳汁的CMV-DNA大多为阳性,其阳性率为90%,两者存在统计学意义(χ2=59.12,P=0.008);新生儿与其母亲CMV-IgM的阳性率分别为6%和2%,但新生儿及其母亲CMV-IgM对新生儿CMV-DNA均没有统计学意义(P>0.05);而新生儿与其母亲CMV-IgG的阳性率分别为78%和92%,分别与新生儿CMV-DNA阳性率比较,均具有统计学意义(χ2=27.248,P=0.004),(χ2=59.158,P=0.007)。结论加强对孕妇产前的产检是预防新生儿CMV感染的重要措施。
Objective To analyze the risk factors of neonatal cytomegalovirus infection and to propose intervention measures. Methods From October 2010 to November 2012 in our hospital for treatment of children with cytomegalovirus infection as a research object, but also selected 45 cases of healthy newborns in our hospital during the same period as a control group, specimens were collected, using PCR, ELISA The levels of CMV-DNA, CMV-IgG and CMVIgM were detected respectively. Results CMV-DNA was positive in 50 of 95 urine samples, and the positive rate was 52.63%. Most CMV-DNA in 50 CMV-DNA-positive mothers ’mothers’ milk was positive, with a positive rate of 90% (Χ2 = 59.12, P = 0.008). The positive rates of CMV-IgM in newborns and their mothers were 6% and 2%, respectively. However, neither newborns nor their mothers had any CMV-IgM in neonates (P> 0.05). The positive rates of CMV-IgG in newborns and their mothers were 78% and 92%, respectively, which were respectively compared with the positive rates of CMV-DNA in neonates (χ2 = 27.248, P = 0.004), (χ2 = 59.158, P = 0.007). Conclusion Strengthening antenatal check-up of pregnant women is an important measure to prevent neonatal CMV infection.