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目的:讨论女性生殖道人乳头状瘤(HPV)感染的类型及临床意义。方法:采用反向寡核苷酸探针杂交技术(PCR-RDB)对1524例女性生殖道标本进行HPV分型检测,分析各型的感染率以及感染病毒与年龄段关系及HPV分型在宫颈病变中的意义。结果:1524分标本共检出HPV阳性279例总体阳性率为18.31%,PCR-RDB技术所涉及到的23种HPV基因型均被检出,其中高危型以16、185、85、2型为主,低危型以11、6型为主,多型混合感染多发生在15岁～25岁和46岁～55岁,随着宫颈糜烂程度的增加多重感染数量也增加。结论:女性生殖道HPV感染高危型以16、18型为主,低危以6、11为主;在预防和治疗宫颈病变时应重视HPV亚型的混合感染。
Objective: To discuss the type and clinical significance of female genital tract human papilloma (HPV) infection. Methods: Reverse transcription-polymerase chain reaction (PCR-RDB) was used to detect HPV genotypes in 1524 female genital specimens. The infection rate of each genotype and the relationship between the virus and age were analyzed. The significance of the disease. Results: The total positive rate of HPV positive in 279 cases was 18.31% in 1524 samples. Twenty-three HPV genotypes were detected in PCR-RDB technique, of which 16,185,85 and 2 were high risk type The main and low-risk type 11,6-based, multi-type mixed infection occurred in 15 years old to 25 years old and 46 years old to 55 years old, with the increase of cervical erosion increased the number of multiple infections. CONCLUSION: The high risk type of female genital tract HPV infection is mainly of type 16 and 18, and the low risk type is mainly of type 6 and 11. In the prevention and treatment of cervical lesions, mixed infection of HPV subtype should be emphasized.