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套细胞淋巴瘤(MCL)是一种具有独特临床病理特征的B细胞非霍奇金淋巴瘤(B-NHL),占所有NHL的3%~10%。MCL具有相对特征性的t(11;14)(q13;q32)遗传学异常和CCND1的过度表达。MCL好发于中老年人,中位发病年龄约60岁,男女比例为(2~4)∶1。MCL临床上常表现为淋巴结、骨髓、外周血和胃肠道等受累,临床病程多呈侵袭性,中位生存时间仅3~5年,本文主要就
Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin’s lymphoma (B-NHL) with unique clinicopathological features, accounting for 3% to 10% of all NHL. MCL has a relatively characteristic t (11; 14) (q13; q32) genetic abnormality and CCND1 overexpression. MCL occurs in the elderly, the median age at onset of about 60 years old, male to female ratio (2 ~ 4): 1. MCL clinically manifested as lymph nodes, bone marrow, peripheral blood and gastrointestinal tract involvement, the clinical course of mostly invasive, the median survival time of only 3 to 5 years, this article mainly