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晚期帕金森病病人药物诱发的精神症状的治疗相当困难。伴痴呆的帕金森病病人常产生幻觉和精神错乱状态。减少抗帕金森病药物或使用传统的神经安定剂均可导致本病症状加重到难以耐受的程度。氯氮平是一种有效的抗精神病药物,该药很少诱发锥体外副作用。以往文献中曾报告过5例震颤麻痹病人药物所诱发的精神症状用氯氮平治疗有效而且不使运动症状加重。本文作者对16侧帕金森病病人药物所诱发的精神症状用氯氮平进行治疗。为了减轻精神症状将抗帕金森病药物的剂量尽量降低,降低到使患者的运
Treatment of patients with advanced Parkinson’s disease drug-induced psychiatric symptoms is quite difficult. Parkinson’s disease patients with dementia often have hallucinations and mental disorders. Reducing anti-Parkinson’s disease drugs or using traditional neuroleptic agents can cause symptoms of this disease to increase to an unacceptable level. Clozapine is an effective antipsychotic and the drug seldom induces extrapyramidal side effects. Previous literature has reported that 5 cases of Parkinson’s disease drug induced psychiatric symptoms with clozapine treatment without exacerbation of motor symptoms. The authors treated patients with Parkinson’s disease in 16 patients with psychiatric symptoms treated with clozapine. In order to reduce the mental symptoms of anti-Parkinson’s disease drugs to minimize the dose, reduced to the patient’s luck