Brugada 综合征伴发的心律失常研究近况

• 作 者: 陈琪 王士雯
• 机 构: 北京中国人民解放军总医院老年心血管病研究所,北京中国人民解放军总医院老年心血管病研究所,
• 出 处: 临床心电学杂志
• 发表日期: 2007年01期
• 关键词: Brugada综合征 心律失常 原发性

Brugada综合征是一种有明显遗传倾向的原发性心电疾病,因常伴发心室颤动导致年青人猝死而备受关注。有关Brugada综合征患者伴有其他快速或缓慢心律失常的报道近年来不断增加,使人们认识到Brugada综合征患者原发性心电病变及基因突变造成的离子通道异常不仅局限在心室肌,可以累及心房肌、传导系统等其他部位而引发相应的各种心律失常。而且,Brugada综合征还可以与其他SCN5A基因突变相关的原发性心电疾病共存而表现出各种不同的心律失常。本文就Brugada综合征伴有的心律失常的研究近况简述如下。

Brugada syndrome is a genetic predisposition of primary heart disease, often associated with ventricular fibrillation caused by sudden death of young people and concern. The reports of other patients with Brugada syndrome accompanied by other rapid or slow arrhythmias have been increasing in recent years, making people realize that abnormalities of ion channels caused by primary electrocardiographic lesions and gene mutations in patients with Brugada syndrome are not only confined to the ventricular muscle and can be involved Atrial muscle, conduction system and other parts caused by the corresponding variety of arrhythmias. Moreover, Brugada syndrome can also exhibit a variety of arrhythmias with the coexistence of primary ECGs associated with mutations in other SCN5A genes. This article on the Brugada syndrome associated with arrhythmia recent developments are summarized below.