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放射治疗是目前非小细胞肺癌的主要治疗手段之一,在放疗过程中,利用功能影像与CT解剖影像相结合,不但提高了肿瘤靶区的勾画精度,而且,还能利用功能影像显示的靶区细胞的生物学特性,进行生物功能图像引导的剂量雕刻(dosepainting)治疗,这是放射治疗发展过程的一个重要转折点。对局部晚期非小细胞肺癌而言,采用累及野照射的方式优于选择性淋巴结照射。利用4D-CT图像引导的个体化靶区勾画、锥形束CT(cone beam CT,CBCT)图像引导放疗和自适应放疗(adaptive radiation therapy,ART)技术的应用,进一步提高了非小细胞肺癌放疔的精度,可望减少放射性肺炎等正常组织损伤、提高肿瘤控制率和改善疗后生存质量。
Radiation therapy is one of the main treatment methods for non-small cell lung cancer. In the course of radiotherapy, the combination of functional imaging and CT anatomical imaging not only improves the accuracy of tumor target area definition, but also makes use of the target of functional image display Regional biological characteristics of cells, the dose-limiting bio-functional image-guided treatment, is an important turning point in the development of radiation therapy. For locally advanced non-small cell lung cancer, the use of radiation involving the field is better than selective lymph node irradiation. The use of 4D-CT image-based individualized target mapping, cone beam CT (CBCT) image guided radiotherapy and adaptive radiation therapy (ART) have further improved the non-small cell lung cancer疔 accuracy, is expected to reduce the normal tissue damage such as radiation pneumonitis, improve tumor control and improve the quality of life after treatment.