吸烟对T细胞亚群的影响

• 作 者: 马燕兰
• 出 处: 国外医学(免疫学分册)
• 发表日期: 1990年04期
• 关键词: 细胞亚群 单克隆抗体 吸烟状况 类固醇药物 华盛顿市 流式细胞仪 特异性 静脉药瘾 淋巴细胞数 白细胞计数

为研究吸烟对单个核细胞亚群的影响,作者用单克隆抗体和流式细胞仪检查了大样本随机分组受试者的T 细胞、B 细胞、单核细胞和HLA—Dr~+细胞亚群。研究对象为华盛顿市区的白人,这可排除种族特异性的影响。从3888个家庭中初选出741名受试者,经进一步筛选,排除了静脉药瘾和同性恋、严重过敏、使用类固醇药物、妊娠以及近期住院史等情况。最后选出的282名受试者年龄在20～69岁之间。其中吸烟者108名,非吸烟者174名。受试者根据年龄、性别和吸烟状况又分为若干组,以便

To investigate the effect of smoking on mononuclear cell subsets, we used monoclonal antibodies and flow cytometry to examine T-cells, B cells, monocytes, and HLA-Dr ~ + cell subsets in large randomized subjects . The study was conducted in whites in downtown Washington, and excludes racially specific effects. A total of 741 subjects were selected from 3,888 families and were further screened to exclude intravenous drug addiction and homosexuality, serious allergies, steroid use, pregnancy, and recent hospitalization. The last 282 subjects selected were between 20 and 69 years of age. Among them, 108 smokers and 174 non-smokers. Subjects were further divided into groups based on age, gender and smoking status