论文部分内容阅读
目的通过分析5292例不良孕产史人群的染色体核型分布,探讨并总结其临床细胞遗传学意义。方法常规培养外周血淋巴细胞,制片后G显带,并对其染色体进行核型分析。结果 5292例患者中共检出非多态性核型(包括染色体数目异常及结构异常)90例,占受检总人数的1.70%;检出染色体多态性204例,占受检总人数的3.85%。两者共294例,染色体核型异常率为5.56%。结论染色体核型异常与不良孕产史的发生有一定的关系。对不孕不育、流产、胚停及生育畸形儿的夫妇进行细胞遗传学检查,可以为临床诊断和治疗提供科学依据。
Objective To analyze and analyze the distribution of chromosomal karyotypes in 5292 cases of poor maternal history and discuss its clinical cytogenetic significance. Methods Peripheral blood lymphocytes were routinely cultured and G banding was performed after the preparation. The karyotypes of the chromosomes were analyzed. Results Among 5292 patients, 90 non-polymorphism karyotypes (including chromosomal abnormalities and structural abnormalities) were detected, accounting for 1.70% of the total; 204 chromosomes were detected, accounting for 3.85 %. A total of 294 cases of both, anomalous rate of chromosome karyotype 5.56%. Conclusion Chromosome karyotype abnormalities and adverse pregnancy history have a certain relationship. On the infertility, miscarriage, embryo stop and reproductive malformations couple of children for cytogenetic examination can provide scientific basis for clinical diagnosis and treatment.