论文部分内容阅读
目的了解合肥市蜀山区居民甲型H1N1流感病毒感染状况和免疫水平,为制定科学有效的防控策略和措施提供基础资料。方法采用分层随机抽样方法,从蜀山区8个街道及1个乡镇选取772人进行问卷调查,收集居民年龄、性别、职业等相关信息,采集血液标本提取甲型H1N1流感病毒血清,应用红细胞血凝抑制试验检测病毒抗体。结果本次调查蜀山区居民甲型H1N1流感抗体阳性率为39.25%(303/772);5个年龄组0～5岁,6～15岁,16～24岁,25～59岁,60岁及以上抗体阳性率分别为31.11%、70.99%、49.04%、28.16%、13.89%;按特定人群比较,学生抗体阳性率(74.29%)高于散居或幼托儿童(31.25%)、教师(33.33%)、医护人员(33.86%)、离退人员(18.32%)以及其他人群(18.18%);按有无甲型H1N1流感疫苗免疫史进行统计,接种组与未接种组的抗体阳性率分别为75.66%、24.18%。蜀山区未接种甲型H1N1流感疫苗人群的隐性感染率为24.64%;蜀山区城区与城乡结合部(井岗镇街道、南岗镇)的居民抗体阳性率分别为32.81%、58.16%,抗体阳性率差异有统计学意义(2=39.41,P<0.001);本次选取的772人中,在2009年5月～2010年1月期间曾患流感样症状病例、普通感冒病例、健康人群的抗体阳性率分别为44.15%、33.00%、39.14%,差异有统计学意义(2=5.99,P=0.050)。结论合肥市蜀山区居民甲型H1N1流感病毒抗体阳性率在不同年龄段、不同人群、不同地区、是否曾有流感样症状、是否有甲型H1N1流感疫苗免疫史等方面均存在不同。
Objective To understand the status and level of influenza A (H1N1) virus infection in residents of Shushan in Hefei and provide basic information for the development of scientific and effective prevention and control strategies and measures. Methods A stratified random sampling method was used to select 772 people from 8 streets and 1 township of Shushan District for questionnaire survey. The information of residents’ age, gender and occupation were collected. Blood samples were collected for the detection of influenza A (H1N1) virus, Condensation inhibition test to detect the virus antibody. Results The positive rate of influenza A (H1N1) antibody in residents of Shushan was 39.25% (303/772) in this survey. The average age of patients in five age groups was 0-5, 6-15, 16-24, 25-59, 60 and The positive rate of antibody was 31.11%, 70.99%, 49.04%, 28.16% and 13.89% respectively. According to specific population, the positive rate of antibody was higher (74.29%) than that of diaspora or child care child (31.25% ), Medical staff (33.86%), retired staff (18.32%) and other groups (18.18%). According to the statistics of the immunization history of Influenza A (H1N1) vaccine, the positive rate of antibody in inoculated group and unvaccinated group was 75.66 %, 24.18%. The latent infection rate in non-vaccinated patients with A (H1N1) vaccine in Shushan was 24.64%. The positive rates of antibodies in urban areas and urban-rural areas (Jinggang Street and Nangang Town) in Shushan were 32.81% and 58.16%, respectively The difference was statistically significant (2 = 39.41, P <0.001). Among the 772 people selected from May 2009 to January 2010, they had flu-like symptoms, common cold cases and healthy people The positive rates of antibodies were 44.15%, 33.00% and 39.14%, respectively (χ2 = 5.99, P = 0.050). Conclusion The prevalence of influenza A (H1N1) virus in residents of Shushan in Hefei City is different in different age groups, different populations and different regions, whether there is any flu-like symptoms and whether there is immunization history of influenza A (H1N1) vaccine.