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对临床常用的三种抗癫痫药(AEDs)苯妥英钠(PHT)、丙戊酸内(VPA)和卡马西平(CBZ)进行胚胎毒性的比较,以期找到一种胚胎毒性较低的AEDs。用人类平均治疗量的10倍AEDs给予怀孕母鼠。孕末时,对其胎鼠进行胚胎毒性的鉴定。PHT组除了上枕骨骨化程度低于对照组外,未见其它胚胎毒性。VPA和CBZ组的胚胎毒性高于对照组。VPA组又高于CBZ组。VPA胚胎毒性最强,CBZ次之,PHT最弱。
To compare the embryotoxicity of phenytoin sodium (PHT), valproate (VPA) and carbamazepine (CBZ) in three kinds of antiepileptic drugs (AEDs) commonly used clinically in the hope of finding a kind of AEDs with low embryo toxicity. Pregnant females were administered 10 times the average human treatment with AEDs. At the end of pregnancy, embryonic mice were identified for their embryotoxicity. PHT group in addition to the lower degree of ossification than the control group, no other embryo toxicity. The embryo toxicity of VPA and CBZ groups was higher than that of control group. VPA group is higher than CBZ group. VPA embryotoxicity strongest, followed by CBZ, PHT the weakest.