IL-10-Producing Type 1 Regulatory T Cells and Allergy

• 作 者: Kui Wu Yutian Bi Kun Sun Chang
• 机 构: Department of Respiratory Disease,Institute of Respiratory Disease
• 出 处: 中国免疫学杂志（英文版）
• 发表日期: 2004年期
• 关键词: allergic disease immune dysregulation interleukin 10 regulatory T cell type 1 re

As an important subset of regulatory T (Treg) cells, IL-10-producing type 1 regulatory T cells (Tr1), have some different features to thymic-derived naturally occurring CD4+CD25+Foxp3+ Treg cells(nTreg cells). Similar to nTreg cells, Tr1 also play important roles in the control of allergic inflammation in several ways. There is a fine balance between Tr1 and Th2 responses in healthy subjects. Skewing of allergic-specific effctor T cells to a Tr1 phenotype appears to be a critical event in successful allergen-specific immunotherapy and glucocorticoids and β2-agonists treatment. Tr1 suppress Th2 cells and effector cells of allergic inflammation, such as eosinophils, mast cells, basophils, through producing IL-10, and perhaps TGF-β. Understanding of Tr1 may be helpful in developing new strategies for treatment of allergic diseases.