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再生障碍性贫血(下称再障)是以骨髓功能衰竭、全血细胞减少为特征的临床综合症。其发病机理至今不甚明了。近年来的临床和实验研究提示其发病机理可分为造血细胞,微环境及免疫缺陷三种类型,一些作者体外骨髓粒系造血祖细胞(GM—CFU)培养证实,部分再障确系造血干细胞缺陷和免疫功能失调所致,但对个体病人有微环境缺陷者尚属推测,临床上尚缺乏一种较普遍接受对个体病人发病机理进行可靠分析的方法。近年来,我们以骨髓基质成纤维细胞(F—CFU)体外生长特点作为造血微环境的指标,比较研究了再障骨髓
Aplastic anemia (hereinafter referred to as aplastic anemia) is a clinical syndrome characterized by bone marrow failure, pancytopenia. Its pathogenesis has so far not clear. In recent years, clinical and experimental studies suggest that the pathogenesis can be divided into three types of hematopoietic cells, microenvironment and immune deficiency. Some of myeloid myeloid hematopoietic progenitor cells (GM-CFU) cultured in vitro confirmed that some of the aplastic anemia are hematopoietic stem cells Defects and immune dysfunction, but individual patients with microenvironment defects are speculated that there is a lack of clinical practice is more generally accepted a reliable analysis of the pathogenesis of individual patients. In recent years, we use the characteristics of bone marrow stromal fibroblasts (F-CFU) in vitro growth as an indicator of hematopoietic microenvironment, comparative study of bone marrow