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目的观察中西医结合治疗过敏性紫癜性肾炎(HSPN)的临床疗效。方法选择HSPN患者60例,随机分为对照组和治疗组各30例。对照组给予常规西医治疗,治疗组在西医基础上给予中医辨证治疗,疗程均为12周。观察两组临床疗效、中医证候积分值、24 h尿蛋白定量及尿红细胞计数的变化情况。结果治疗组临床疗效总有效率为90.00%,优于对照组的73.33%(P<0.05);治疗组治疗后中医证候积分值较治疗前明显下降,优于对照组(P<0.01);治疗组和对照组治疗后24 h尿蛋白定量、尿红细胞计数均较治疗前降低(P<0.01),治疗组下降明显(P<0.05或P<0.01)。结论中西医结合治疗HSPN患者临床疗效确切,优于单纯西医治疗。
Objective To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of allergic purpura nephritis (HSPN). Methods 60 patients with HSPN were randomly divided into control group and treatment group, 30 cases each. The control group was given routine Western medicine treatment, and the treatment group was given TCM syndrome differentiation treatment on the basis of western medicine. The course of treatment was 12 weeks. The clinical curative effect, TCM syndrome integral value, 24 h urinary protein quantitation and urine red blood cell count were observed. Results The total effective rate of the treatment group was 90.00%, which was better than that of the control group (73.33%, P <0.05). The TCM syndrome score of the treatment group was significantly lower than that of the control group after treatment (P <0.01). Urine protein and urinary red blood cell count decreased 24 h after treatment in the treatment group and the control group (P <0.01), and decreased significantly in the treatment group (P <0.05 or P <0.01). Conclusion The clinical efficacy of integrated traditional Chinese and western medicine in treating patients with HSPN is better than western medicine alone.