【摘 要】
：
本文主要研究基于磁性的CTC捕获芯片中细胞受力情况,提出该类芯片中细胞捕获可分为偏移阶段和吸附阶段,并使用COMOSL软件分析了各个阶段的受力特点。通过模拟计算及实验结果
【机 构】
：
湖北省中国人民解放军武汉总医院骨科,微米纳米加工技术国家级重点实验室薄膜与微细技术教育部重点实验室上海交通大学微纳科学技术研究院,
论文部分内容阅读
本文主要研究基于磁性的CTC捕获芯片中细胞受力情况,提出该类芯片中细胞捕获可分为偏移阶段和吸附阶段,并使用COMOSL软件分析了各个阶段的受力特点。通过模拟计算及实验结果可以看出,传统的垂直捕获模式由于其受流场作用力影响,不适合在高流速下进行CTC细胞捕获。基于此我们提出一种新型的平行捕获模式芯片的设计,该设计可以显著减少流场对CTC细胞捕获的影响。优化后的芯片流速可以达到6ml/h。
In this paper, we mainly study the cell stress in magnetic CTC capture chip. It is suggested that the cell capture in this kind of chip can be divided into the offset phase and the adsorption phase, and the force characteristics of each phase are analyzed by COMOSL software. Through the simulation and experimental results, we can see that the traditional vertical capture mode is not suitable for CTC trapping at high flow rates because of its influence on the flow field. Based on this, we propose a novel parallel capture mode chip design that can significantly reduce the impact of flow field on CTC cell capture. Optimized chip flow rate can reach 6ml / h.
其他文献
肝癌的治疗模式已由过去的单一外科转变为以外科切除为主的多学科综合治疗模式.而在多种治疗方法中,以射频消融(radiofrequency ablation,RFA)为代表的局部消融治疗进展迅速,
Single nucleotide polymorphism (SNP) is a common form of genetic variation and popularly exists in maize genome.An Illumina GoldenGate assay with 1 536 SNP mark
The competition between submersed plants has been recognized as an important factor influencing the structure of plant communities in shallow lakes.The ability
Nitric oxide-associated protein 1 (NOA1) is involved in various abiotic stress responses and is required for plant resistance to pathogen infections.However,the
Background Distal pancreatectomy traditionally included splenectomy; the spleen, however, is an important organ in the immunologic defense of the host and is wo
Pyropia haitanensis is an economically important mariculture crop in China and has a high research value for several life phenomena, for example environmental t
利用自行设计建造的处理量为2.5t/d大型流化床气化实验平台,在反应温度为550～750℃、空气系数0.4的工况下,对模拟垃圾(municipal solid waste,MSW)进行了气化试验研究,讨论反
Agrobacterium radiobacter MTCC 8161 completely decolorized the Crystal Violet with 8 hr (10 mg/L) at static anoxic conditions.The decreased decolorization capab
介绍了该机组的空气处理过程.机组夏季出风参数主要与进风参数、进水温度、风水比、直接蒸发制冷段效率有关.在分析影响因素的基础上,绘制了机组在不同地区应用时的夏季出风
In the past two decades, many studies have focused on the classification within genus Laminaria, ultimately trying to divide it into two subgroups or genera:Lam