论文部分内容阅读
由抗体介导的中和作用有多种不同的机制:(1)通过凝集病毒,使病毒的结构失稳,抑制病毒对靶细胞的吸附;(2)抑制病毒的类脂膜与宿主细胞膜的融合,抑制无包膜病毒基因组进入宿主细胞;(3)通过IgA作用于细胞内的信号转导途径来抑制病毒核心蛋白的功能;(4)结合新生病毒,阻碍其芽生或从细胞表面释放。人们对抗体的抗病毒作用的研究历时已久,其介导的中和作用方式纷繁复杂,但一直存在争议,可以肯定的是任何一种病毒在感染早期都可被特异性抗体以不同的方式中和。在此就抗体介导的中和作用作一概述。
Antibody-mediated neutralization has a number of different mechanisms: (1) destabilizing the virus structure by agglutinating the virus, inhibiting the virus’s adsorption to target cells; (2) inhibiting the viral lipid membrane from the host cell membrane Fusion, and inhibit the entry of non-enveloped virus genome into the host cell; (3) inhibition of the function of the viral core protein through the signal transduction pathway of IgA in the cell; and (4) binding to the neoplastic virus to prevent its budding or release from the cell surface. It has been controversial for many years to study the antiviral effect of antibodies against HIV and its mediating effects have been complicated. What is certain is that any virus can be detected by specific antibodies in different ways neutralize. Antibody-mediated neutralization is outlined here.