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本文综述了近年来关于碘硒缺乏研究的进展。这两种微量元素可控制硒蛋白 m RNA水平 ,特别是在甲状腺和脑。当碘和硒的供给有限时 ,补偿机制可减少对甲状腺激素代谢和神经发育的不良影响。但是 ,在硒、碘缺乏时 ,硒蛋白调节机制是很有组织特异性的。例如 ,棕色脂肪组织与脑和甲状腺不同 ,在碘、硒缺乏时 ,不能保存硒蛋白 ,所以存在缺碘缺硒致损伤的更大危险性。
This review summarizes recent advances in iodine-selenium deficiencies. These two trace elements control selenoprotein m RNA levels, especially in the thyroid and brain. When the supply of iodine and selenium is limited, the compensation mechanism can reduce the adverse effects on thyroid hormone metabolism and neurodevelopment. However, in the selenium, iodine deficiency, selenoprotein regulatory mechanism is very tissue-specific. For example, different from brain and thyroid, brown adipose tissue can not store selenoproteins when iodine and selenium are deficient, so there is a greater risk of injury due to iodine deficiency and selenium deficiency.