论文部分内容阅读
儿童神经精神性狼疮(NPSLE)是系统性红斑狼疮(SLE)的严重并发症,可发生于SLE病程的任何阶段,其可能的发病机制是多方面的,包括自身抗体的产生、微血管病变、鞘内前炎性因子的产生和过早的动脉粥样硬化等。其临床表现复杂多样,中枢神经系统症状在儿童常见,可以出现严重的反复发作性头痛、癫发作、脑血管意外及精神症状。综合运用血清学、脑脊液检查、神经影像学检查有助于NPSLE的诊断。治疗主要应用免疫抑制剂和对症处置。早期诊断、积极治疗可能有助于改善患儿的预后。
Childhood neuropathic lupus (NPSLE) is a serious complication of systemic lupus erythematosus (SLE) and may occur at any stage of SLE’s course of disease. Its possible pathogenesis is multifaceted, including autoantibodies, microangiopathy, sheath Production of pre-inflammatory factors and premature atherosclerosis. The clinical manifestations of complex and diverse, central nervous system symptoms common in children, you can have severe recurrent headache, epileptic seizures, cerebrovascular accidents and mental symptoms. Comprehensive use of serology, cerebrospinal fluid examination, neuroimaging can contribute to the diagnosis of NPSLE. The main treatment of immunosuppressive agents and symptomatic treatment. Early diagnosis, aggressive treatment may help to improve the prognosis of children.