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目的分析甘草酸二铵不良反应的临床特征和相关因素,为合理用药提供参考依据。方法检索国内关于甘草酸二铵不良反应的文献,并进行统计分析。结果 60例不良反应病例报告中,男性明显多于女性;21~60岁年龄段的患者多见(43例,71.7%);不良反应以过敏反应为主,其次是高血压和低钾血症。致不良反应机制主要涉及IgE介导的变态反应和假性醛固酮增多症。出现各种不良反应的患者总体预后较好。结论甘草酸二铵不良反应临床并不少见,尤其要重视过敏性休克和低钾血症。
Objective To analyze the clinical characteristics and related factors of adverse reactions of diammonium glycyrrhizinate and provide a reference for rational drug use. Methods The domestic literature about adverse reactions of diammonium glycyrrhizinate was retrieved and analyzed statistically. Results Among the 60 cases of adverse reactions, the number of male patients was significantly higher than that of females. The patients in 21-60 years old were more common (43 cases, 71.7%). The adverse reactions were mainly anaphylaxis, followed by hypertension and hypokalemia . The mechanism of adverse reactions mainly involves IgE-mediated allergy and pseudo-aldosteronism. Patients with various adverse reactions overall prognosis is good. Conclusion Adverse reactions of diammonium glycyrrhizinate are not uncommon clinically, with particular emphasis on anaphylactic shock and hypokalemia.