越南巴豆中的细胞毒二萜类成分

• 作 者: 陈蕙芳
• 出 处: 国外医药(植物药分册)
• 发表日期: 2005年06期
• 关键词: 越南巴豆 细胞毒活性 二萜类 化合物 药用植物 正丁醇 甲醇提取 叶中 己烷 乙酸乙酯

作者从药用植物越南巴豆Croton tonki-nensis Gagnep.叶中分离出6个新的贝壳杉烷类二萜化合物(2～4、6、8和14)以及3个已知化合物(1、5和7),鉴定了新化合物的结构,并用海幼虾致死试验检测了它们的细胞毒活性。将该植物叶的干粉以甲醇提取,然后用极性递增的正己烷、二氯甲烷、乙酸乙酯、正丁醇和水分配提取,合并正己烷和二氯甲烷部位,经硅胶柱层析,以正己烷-乙酸乙酯

The authors isolated six new kaurizan diterpenoids (2~4, 6, 8 and 14) and three known compounds (1,5 and 5) from the medicinal plant Crotontonki-nensis Gagnep. 7) The structure of the new compounds was identified and their cytotoxic activity was tested using the sea juvenile shrimp lethal test. The plant leaf dry powder was extracted with methanol and then extracted with increasing polarity of n-hexane, methylene chloride, ethyl acetate, n-butanol and water. The n-hexane and methylene chloride parts were combined and subjected to silica gel column chromatography. N-hexane-ethyl acetate