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作者回顾性研究以色列一所大学医院生殖中心1960～1984年间所有不育妇女情况。不孕时间＞1年，共计有1197例不孕患者，其中78O例（6．2％）为使用促生殖药物组，417例（34．8％）为未服用药物组，两组分别随访了14O65妇女年（65．8％）及7342年（342％）。按研究人数平均随访17.9±5．3年（范围2～35年）。674例（56．3％）患者为原发不孕，523例（43．7％）为继发不孕。不孕症类型分为：激素型（如闭经等）有539例（45％），机械型（如内异症）有297例（24．8％），男性因素有345例问88％），原因不明不孕16例（1．4％）。不孕症类型，出身种族及首次就诊时年龄两组无显著差异。乳腺癌患者组织中测得的ER、PR含量若）10fmol／mg定为阳性。所有数据经统计学处理，应用群体癌症标准发病率及95％可信线（CI）评估癌症危险。结果：共计有38例不孕症者患癌症，用生殖药及未用生殖药两级分别为25例（1．09），13例（1．O7），与癌症标准发病率1．09（95％CIO．77～l．49）相比，未增加癌症发病危险。38例癌症中28例为妇科癌症，其中20例为乳腺癌，2例卵巢癌，2例子宫体癌，4例宫颈癌。78O例不孕妇女共计3978个治疗周期，其中6O3例接受了周87个CC治疗周期，16例接受了49个l。MG治疗周期，单用hMG周期者无恶性?
The authors retrospectively studied the status of all infertile women in a reproductive center of a university hospital in Israel from 1960 to 1984. Infertility time >1 year, a total of 1197 cases of infertility patients, including 78O cases (6.2%) for the use of procreative drugs group, 417 cases (34.8%) for the non-drug group, the two groups were followed up 14O65 Women’s Year (65.8%) and 7342 (342%). The average number of follow-up studies was 17.9 ± 5.3 years (range, 2 to 35 years). 674 patients (56.3%) had primary infertility and 523 (43.7%) had secondary infertility. Types of infertility are divided into 539 cases (45%) for hormones (such as amenorrhea, etc.), 297 cases (24.8%) for mechanical (such as endometriosis), and 345 cases (88% for men). Unexplained infertility in 16 cases (1.4%). There were no significant differences between the two groups in the type of infertility, age of origin, and age of first visit. The ER and PR levels measured in breast cancer patients were determined to be positive at 10 fmol/mg. All data were statistically processed and the cancer risk was assessed using the standard incidence of colon cancer and the 95% confidence level (CI). Results: A total of 38 cases of infertility were diagnosed as having cancer. There were 25 cases (1.09) and 13 cases (1.O7) of reproductive and non-reproductive drugs, respectively, and the standard incidence of cancer was 1.09 ( Compared with 95% CIO.77 to 1.49, there was no increase in the risk of cancer. Of the 38 cancers, 28 were gynecological cancers, of which 20 were breast cancers, 2 ovarian cancers, 2 uterine body cancers, and 4 cervical cancers. 78O cases of infertile women totaled 3978 treatment cycles, of which 6O3 received 87 cycles of CC treatment and 16 received 49 l. MG treatment cycle, single hMG cycle without malignant?