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本文报告一例慢性间歇性黄疸患者。黄疸的出现与感染或劳累饮酒有关,有血中结合与非结合胆色素增多,尿三胆阳性、胆囊造影不显影BSP试验180分钟仍有滞留,肝功能接近正常。症状除黄疸外,无其他不适。经剖腹探查肝组织检查发现肝内有黑色素样颗粒,符合Dubin-Johnson氏综合征的病变。结合本例复习了国内外有关Dubin-Johnson氏综合征的部分文献,对此病的临床表现、病理特点、发病机理、诊断作了简单的讨论。
This article reports a patient with chronic intermittent jaundice. The appearance of jaundice and infection or exertion related to drinking, there is a combination of blood and uncoated bile pigment, urine three gallbladder, cholecystography is not developing BSP test 180 minutes still remain, liver function close to normal. In addition to jaundice, no other discomfort. The laparotomy liver tissue examination revealed melanin-like particles in the liver, in line with the Dubin-Johnson’s syndrome lesions. In this paper, we review some of the literature about Dubin-Johnson’s syndrome at home and abroad, and briefly discuss the clinical manifestations, pathological features, pathogenesis and diagnosis of this disease.